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Engelie net new use! The latest research from Southern Medical University shows that SGLT2 inhibitors promote ketogenic and improve MASH by inhibiting CD8 T cell activation.
2024-09-09 23:00
Accumulation of autoaggressive CD8 T cells contributes significantly to liver injury and inflammation during the progression of metabolic dysfunction-associated steatohepatitis (MASH). EMPA, a highly selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has potential therapeutic effects on hepatic steatosis; however, the underlying mechanism has not been fully elucidated.
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05
2024-09
Tuberculosis (TB) is a global infectious disease mainly caused by Mycobacterium tuberculosis (MTB). In recent years, there have been more than 10 million new cases of tuberculosis and more than 1.6 million deaths worldwide each year, making MTB the second leading infectious agent in the world, second only to SARS-CoV-2 and surpassing HIV. The emergence and continuous increase of drug-resistant tuberculosis have made the global tuberculosis epidemic more serious.
04
2024-09
Sun Yat-sen University Xu Ruihua Team's Latest STTT
Patients carrying polymerase epsilon/polymerase delta mutations exhibit positive responses to immune checkpoint inhibitors. However, prospective trials of efficacy in patients with polymerase epsilon/polymerase delta mutations are still lacking.
01
2024-09
Lung regeneration after fibrosis requires the formation of a functional neovasculature, which is critical for gas exchange and cellular crosstalk with other lung cells. It is not clear how the pulmonary blood vessels regenerate in the absence of fibrosis.
26
2024-08
Gastric cancer (GC), the sixth largest cancer type in the world and the third largest cause of death, is considered to be highly heterogeneous both histologically and genetically. Despite the clinical progress of anti-HER2 targeted therapy and anti-PD-1/PD-L1 immunotherapy, there is still a lack of specific treatment for gastric cancer.
20
2024-08
Sleep is essential for overall health, and disrupted sleep increases the risk of metabolic, cognitive, and cardiovascular dysfunction; however, the molecular mechanisms remain poorly understood.
19
2024-08
Kisspeptin receptor (KISS1R) belongs to the class A peptide-gpcr family, plays a key role in the regulation of reproductive physiology after Kisspeptin stimulation, and is considered to be an attractive drug target for the treatment of reproductive diseases.
19
2024-08
The gene encoding NUAK family kinase 1(NUAK1) is frequently amplified and its expression is upregulated, activating oncogenic signals in various cancers. However, little is known about its role in gastric cancer (GC).
19
2024-08
Lysosomes are essential degradation organelles and signaling centers in cells, and play a vital role in regulating macroautophagy/autophagy. Lysosomal dysfunction and impaired autophagy are closely related to the development of various neurodegenerative diseases.
15
2024-08
Nature: Mitochondrial complex I promotes renal cell carcinoma metastasis
Metabolic dysfunction is present in most renal cancers, but how this dysfunction affects cancer progression in humans is unclear.
10
2024-08
Leucine-rich glioma-inactivating protein 1(LGI1) is a protein secreted in the brain and plays a key role in myelination; dysfunction of this protein results in hypomelination and white matter abnormalities (WMAs).
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