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2024
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09
Wang Su's team at Southeast University found that microenvironmental glial cells regulate stem cell self-renewal and differentiation by delivering iron to neural stem cells through ferritin
Author:
When there is a lack of iron in the food, the brain development of the fruit fly is obviously defective and the volume becomes smaller. After further observation, iron deficiency will lead to a decrease in the number of neural stem cells, decreased proliferation. In addition, the team found that knocking down the ferritin-encoding gene that stores iron in glial cells can also lead to brain development defects, a decrease in the number of stem cells, and a significant decline in proliferation. Next to explore the mechanism, the authors found that ferritin in glial cells will be transported to stem cells, providing them with iron, so as to maintain the energy production of stem cells, so that they can carry out normal self-renewal and proliferation. Combined with the data of Shengxin, the NAD of stem cells after knocking down ferritin was further determined.+Defects in generation, energy generation, biosynthesis, etc. More importantly, energy production can be partially restored by overexpressing NADH dehydrogenase Ndi1 in stem cells, rescuing the stem cell loss phenotype. After a series of analysis, it was finally proved that the loss of stem cells caused by ferritin knockdown was caused by the lack of energy and the early differentiation of stem cells, rather than due to the origin defect or apoptosis.
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